What are evidence-based treatment recommendations?

How Evidence-Based Are the Recommendations in Evidence-Based Guidelines?

BACKGROUND Treatment recommendations for the same condition from different guideline bodies often disagree, even when the same randomized controlled trial (RCT) evidence is cited. Guideline appraisal tools focus on methodology and quality of reporting, but not on the nature of the supporting evidence. This study was done to evaluate the quality of the evidence (based on consideration of its int...

What are the "ingredients" of modified constraint-induced therapy? An evidence-based review, recipe, and recommendations.

Modified constraint induced movement therapy (mCIT) increases paretic upper extremity use and movement in all phases of stroke. Although fundamental to its appropriate implementation, specific details on day to day implementation on this promising family of therapies have not heretofore been published. Consequently, some integral behavioral facets of mCIT may be overlooked, while other approach...

What are Stem Cells?

  Stem cells are undifferentiated self regenerating multi potential cells. There are three types of stem cells categories by the ability to form after cells and correlated with the body’s development process. Totipotent: these stem cells can form an entire organism such as fertilized egg. Ploripotent: ploripotent cells are those that can form any cell in the body but cannot form an entire organ...

Mechanisms: what are they evidence for in evidence-based medicine?

Even though the evidence-based medicine (EBM) movement labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between EBM and mechanisms from several angles. I diagnose what went wrong i...

WHO evidence based recommendations on the treatment of tobacco dependence.